| 20512 |
P56564 |
EAA1_MOUSE |
Excitatory amino acid transporter 1 (Glial high affinity glutamate transporter) (High-affinity neuronal glutamate transporter) (GluT-1) (Sodium-dependent glutamate/aspartate transporter 1) (GLAST-1) (Solute carrier family 1 member 3) |
DISRUPTION PHENOTYPE |
No visible phenotype (PubMed:15363892, PubMed:15390100). Mutant mice display normal locomotion, motor coordination and learning, and globally normal glutamate uptake in brain vesicle preparations (PubMed:15363892). The decay time of glutamate receptor mediated excitatory postsynaptic currents (EPSCs) in cerebellar Purkinje is slightly increased (PubMed:15363892). The decreased rate of glutamate uptake in retina Mueller cells from mutant mice suggests that Slc1a3 accounts for about half of the glutamate uptake activity in wild-type cells (PubMed:15390100). Mice deficient in both Slc1a2 and Slc1a3 die at about 17 dpc (PubMed:16880397). {ECO:0000269|PubMed:15363892, ECO:0000269|PubMed:15390100, ECO:0000269|PubMed:16880397}. |