Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 20597
  • Symbol: Smpd1
  • Description: sphingomyelin phosphodiesterase 1, acid lysosomal
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Gene ID Entry Entry Name Protein Name Type Information
20597 Q04519 ASM_MOUSE Sphingomyelin phosphodiesterase (EC 3.1.4.12) (EC 3.1.4.3) (Acid sphingomyelinase) (ASMase) [Cleaved into: Sphingomyelin phosphodiesterase, processed form] DISRUPTION PHENOTYPE Mutants infected with Pseudomonas aeruginosa die within 7 days whereas all wild-type mice survive the infection (PubMed:12563314). Mutants are defective in radiation-induced apoptosis (PubMed:8706124). {ECO:0000269|PubMed:12563314, ECO:0000269|PubMed:8706124}.