Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 20678
  • Symbol: Sox5
  • Description: SRY (sex determining region Y)-box 5
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Gene ID Entry Entry Name Protein Name Type Information
20678 P35710 SOX5_MOUSE Transcription factor SOX-5 DISRUPTION PHENOTYPE Newborn mice display mild skeletal abnormalities (PubMed:11702786). Mice lacking both Sox5 and Sox6 develop a severe chondrodysplasia characterized by the virtual absence of cartilage: chondrogenic cells are largely arrested at the stage of chondrogenic mesenchymal condensations (PubMed:11702786). Embryos lacking Sox5 (homozygous knockout) and heterozygous for Sox6 live until birth and show severe growth plate chondrocyte defects (PubMed:14993235). Embryos lacking Sox6 (homozygous knockout) and heterozygous for Sox5 live until birth and show severe growth plate chondrocyte defects (PubMed:14993235). {ECO:0000269|PubMed:11702786, ECO:0000269|PubMed:14993235}.