Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 20773
  • Symbol: Sptlc2
  • Description: serine palmitoyltransferase, long chain base subunit 2
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Gene ID Entry Entry Name Protein Name Type Information
20773 P97363 SPTC2_MOUSE Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2) DISRUPTION PHENOTYPE Adipocyte-specific knockout mice have reduced adipose tissue mass and develop hepatosteatosis with insulin resistance and hyperglycemia. {ECO:0000269|PubMed:27818258, ECO:0000269|PubMed:28698261}.