Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 212712
  • Symbol: Satb2
  • Description: special AT-rich sequence binding protein 2
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Gene ID Entry Entry Name Protein Name Type Information
212712 Q8VI24 SATB2_MOUSE DNA-binding protein SATB2 (Special AT-rich sequence-binding protein 2) DISRUPTION PHENOTYPE Malformations in 2 of the major axonal tracts interconnecting the cortical hemispheres: the corpus callosum (c.c) and the anterior commissure (a.c). Misrouted afferent and efferent cortical axon connections. Impaired migration of upper-layer neurons. Ectopic expression of Ctip2. Craniofacial abnormalities and defects in osteoblast differentiation and function. {ECO:0000269|PubMed:16751105, ECO:0000269|PubMed:18255030, ECO:0000269|PubMed:18255031}.