| 214133 |
Q4JK59 |
TET2_MOUSE |
Methylcytosine dioxygenase TET2 (EC 1.14.11.80) (Protein Ayu17-449) |
DISRUPTION PHENOTYPE |
Mice are viable and fertile but develop chronic myelomonocytic leukemia probably caused by dysregulation of hematopoietic stem cells. Mice lacking both Tet1 and Tet2 are fertile, with females having smaller ovaries and reduced fertility. They display decreased 5-hydroxymethylcytosine (5hmC) and abnormal methylation at various imprinted loci. Embryonic stem cells lacking both Tet1 and Tet2 remain pluripotent but lack 5hmC, leading to developmental defects in chimeric embryos. {ECO:0000269|PubMed:21723200, ECO:0000269|PubMed:21803851, ECO:0000269|PubMed:23352810}. |