Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 215095
  • Symbol: Astl
  • Description: astacin like metalloendopeptidase
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Gene ID Entry Entry Name Protein Name Type Information
215095 Q6HA09 ASTL_MOUSE Astacin-like metalloendopeptidase (EC 3.4.-.-) (Oocyte astacin) (Ovastacin) (Sperm acrosomal SLLP1-binding protein) DISRUPTION PHENOTYPE Absence of cortical granules exocytosis during post-fertilization. Multiple capacitated sperm binding to eggs and two-cell embryos are not prevented. Post-fertilization cleavage of ZP2 does not occur. {ECO:0000269|PubMed:22206759, ECO:0000269|PubMed:22472438}.