Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 216227
  • Symbol: Slc17a8
  • Description: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
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Gene ID Entry Entry Name Protein Name Type Information
216227 Q8BFU8 VGLU3_MOUSE Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8) DISRUPTION PHENOTYPE Mice are hyperactive and suffer from intermittent, spontaneous cortical seizures. They exhibit reduced cholinergic transmission in the ventral portion of the striatum and defective acetylcholine release. They are hypersensitive to cocaine and less prone to haloperidol-induced catalepsy. {ECO:0000269|PubMed:18215623, ECO:0000269|PubMed:18278042, ECO:0000269|PubMed:18674745}.