| 218952 |
Q8CIB5 |
FERM2_MOUSE |
Fermitin family homolog 2 (Kindlin-2) (Pleckstrin homology domain-containing family C member 1) |
DISRUPTION PHENOTYPE |
Complete embryonic lethality at peri-implantation stage, due to severe detachment of the endoderm and epiblast from the basement membrane. Heterozygous mice lacking one copy of Fermt2 show no visible phenotype, but show decreased tumor angiogenesis upon transplantation of tumor cells, and their blood vessels are abnormally leaky. {ECO:0000269|PubMed:18174465, ECO:0000269|PubMed:18483218, ECO:0000269|PubMed:21378273}. |