| Gene ID | Entry | Entry Name | Protein Name | Type | Information | 22036 | Q8VIG6 | TRAIP_MOUSE | E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (TRAF-interacting protein) | DISRUPTION PHENOTYPE | Early embryonic lethality due to proliferation defects and excessive cell death (PubMed:17927961). TRAIP knockdown substantially increases LPS- and poly(I:C)-induced IFN-production in mouse peritoneal macrophages at both mRNA and protein levels (PubMed:22945920). {ECO:0000269|PubMed:17927961, ECO:0000269|PubMed:22945920}. |
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