| 224143 |
Q8BYB9 |
PGLT1_MOUSE |
Protein O-glucosyltransferase 1 (EC 2.4.1.376) (CAP10-like 46 kDa protein) (KTEL motif-containing protein 1) (O-glucosyltransferase Rumi homolog) (Rumi) (Protein O-xylosyltransferase POGLUT1) (EC 2.4.2.63) (Wing-shaped neural plate protein) (Wsnp) |
DISRUPTION PHENOTYPE |
Mutant embryos die at or before 9.5 dpc. At 7.0 to 7.5 dpc, they cannot be morphologically distinguished from wild-type littermates (PubMed:21490058, PubMed:26496195). At 8.0 dpc, mutant embryos exhibit an abnormally expanded neural plate that does not fold properly, absence of heart rudiments and posterior axis truncation (PubMed:21490058). Defects are caused by a deficit of mesoderm caused by impaired gastrulation. {ECO:0000269|PubMed:21490058, ECO:0000269|PubMed:26496195}. |