Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 233489
  • Symbol: Picalm
  • Description: phosphatidylinositol binding clathrin assembly protein
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Gene ID Entry Entry Name Protein Name Type Information
233489 Q7M6Y3 PICAL_MOUSE Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia) (CALM) DISRUPTION PHENOTYPE PICALM-deficient mice suffer from severe anemia due to ineffective erythropoiesis in the bone marrow. In addition, they exhibit impaired clathrin-mediated internalization of transferrin leading to iron metabolism abnormalities. {ECO:0000269|PubMed:12832620, ECO:0000269|PubMed:22363754}.