| 236794 |
A1L3P4 |
SL9A6_MOUSE |
Sodium/hydrogen exchanger 6 (Na(+)/H(+) exchanger 6) (NHE-6) (Sodium/hydrogen exchanger) (Solute carrier family 9 member 6) |
DISRUPTION PHENOTYPE |
The SLC9A6 null mice show a 10-20% increased mortality after birth, yet the surviving mice do not display any obvious difference. Behavioral tests reveal a modest motor hyperactivity associated with coordination deficits and limited ataxia. Neurons from these deficient mice exhibit endosomal hyperacidification, as well as impoverished neuronal arborization and attendant circuit dysfunction. {ECO:0000269|PubMed:24035762}. |