Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 237831
  • Symbol: Slc13a5
  • Description: solute carrier family 13 (sodium-dependent citrate transporter), member 5
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Gene ID Entry Entry Name Protein Name Type Information
237831 Q67BT3 S13A5_MOUSE Na(+)/citrate cotransporter (NaCT) (Sodium-coupled citrate transporter) (Sodium-dependent citrate transporter) (Solute carrier family 13 member 5) DISRUPTION PHENOTYPE Mice show increased propensity for epileptic seizures, proepileptogenic neuronal excitability changes in the hippocampus, and significant citrate level alterations in the CSF and brain tissue (PubMed:32682952). Null mice show perturbations in fatty acids, bile acids, and energy metabolites in liver, serum, and brain (PubMed:35448538). {ECO:0000269|PubMed:32682952, ECO:0000269|PubMed:35448538}.