Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 260298
  • Symbol: Fev
  • Description: FEV transcription factor, ETS family member
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Gene ID Entry Entry Name Protein Name Type Information
260298 Q8QZW2 FEV_MOUSE Protein FEV (PC12 ETS domain-containing transcription factor 1) (PC12 ETS factor 1) (Pet-1) (mPet-1) DISRUPTION PHENOTYPE Mice display heightened aggressive and anxiety-like behaviors. They also display an extended and exacerbated period of breathing instability immediately after birth which results in an increased risk of death. This is associated with loss of the differentiation of a large number of the serotonin (5-HT) neurons without major structural abnormalities of the brain. {ECO:0000269|PubMed:12546819, ECO:0000269|PubMed:17656160}.