Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 26380
  • Symbol: Esrrb
  • Description: estrogen related receptor, beta
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Gene ID Entry Entry Name Protein Name Type Information
26380 Q61539 ERR2_MOUSE Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2) DISRUPTION PHENOTYPE Homozygote Esrrb mutant embryos die at 10.5 dpc. They have severely impaired placental formation. The mutants display abnormal chorion development associated with an overabundance of trophoblast giant cells and a severe deficiency of diploid trophoblast (PubMed:9285590). Conditional knockdown mice exhibit head bobbing and spinning and running in circles and have hearing impairment (PubMed:17765677). {ECO:0000269|PubMed:17765677, ECO:0000269|PubMed:9285590}.