| 319984 |
Q80WT0 |
JPH4_MOUSE |
Junctophilin-4 (JP-4) (Junctophilin-like 1 protein) |
DISRUPTION PHENOTYPE |
Jph3 and Jph4 double null mutants exhibit atypical depolarizing responses, irregular cerebellar plasticity due to abolished crosstalk in Purkinje cells. There is hyperphosphorylation of PRKCG and mild impairment of synaptic maturation. Exploratory activity, hippocampal plasticity and memory are impaired and there is abnormal foot-clasping reflex. {ECO:0000269|PubMed:16809425, ECO:0000269|PubMed:17904530}. |