| 331004 |
Q8BZ00 |
SL9A9_MOUSE |
Sodium/hydrogen exchanger 9 (Na(+)/H(+) exchanger 9) (NHE-9) (Solute carrier family 9 member 9) |
DISRUPTION PHENOTYPE |
Deficient mice do not show obvious changes in gross hippocampal morphology or impairments in locomotion, anxiety, smell, or pain sensitivity, however they display autism-like traits, such as reduced ultrasonic vocalization (number of calls and duration), decreased preference for social novelty, and display an increased time self-grooming (PubMed:26755066). Nervous system-specific conditional knockout mice show abnormal social and olfactive behavior, abnormal CNS synaptic transmission, impaired synaptic vesicle exocytosis, impaired presynaptic calcium entry, and decreased synaptic vesicle pH (PubMed:29362376). {ECO:0000269|PubMed:26755066, ECO:0000269|PubMed:29362376}. |