| 338521 |
Q5MPP0 |
FA2H_MOUSE |
Fatty acid 2-hydroxylase (EC 1.14.18.-) (Fatty acid alpha-hydroxylase) |
DISRUPTION PHENOTYPE |
Knockout mice have normal oligodentrocyte differentiation and develope structural and functional normal myelin up to early adulthood. However, aged knockout mice show a massive axon and myelin sheath degeneration in the spinal cord (PubMed:18815260). Knockout mice show delayed fur development and a cyclic alopecia (PubMed:21628453). {ECO:0000269|PubMed:18815260, ECO:0000269|PubMed:21628453}. |