Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 50754
  • Symbol: Fbxw7
  • Description: F-box and WD-40 domain protein 7
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Gene ID Entry Entry Name Protein Name Type Information
50754 Q8VBV4 FBXW7_MOUSE F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10) DISRUPTION PHENOTYPE Whole body FBW7 knockout is embryonic lethal. Conditional knockout mice in which FBW7 expression is specifically abolished in osteoclasts display severe bone resorption, bone fragility and low bone mass (PubMed:29149593). Conditional knockout in liver reduces the amplitude of the diurnal expression of many core clock genes and the altered expression of a large number of genes controlling liver metabolic pathways (PubMed:27238018). {ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:29149593}.