Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 50873
  • Symbol: Prkn
  • Description: parkin RBR E3 ubiquitin protein ligase
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Gene ID Entry Entry Name Protein Name Type Information
50873 Q9WVS6 PRKN_MOUSE E3 ubiquitin-protein ligase parkin (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) DISRUPTION PHENOTYPE In brain, increased protein levels of p53/TP53 and CHPF (PubMed:19801972, PubMed:22082830). Cortical neurons display a slight increase in process fragmentation but no dendritic retraction (PubMed:24898855). {ECO:0000269|PubMed:19801972, ECO:0000269|PubMed:22082830, ECO:0000269|PubMed:24898855}.