| 50933 |
Q9JKB1 |
UCHL3_MOUSE |
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3) |
DISRUPTION PHENOTYPE |
Mice have no developmental defects, are fertile, and show normal T-cell differentiation. They have normal anxiety, locomotor behavior, motor function and synaptic transmission, but show defects in spatial learning and working memory. Exhibit stress-related effects with profound apoptosis-mediated germ cell loss and also, prominent retinal degeneration with photoreceptor cell apoptosis and mitochondrial oxidative stress. Mice show reduced capacity for adipocyte differentiation and impaired insulin responses. {ECO:0000269|PubMed:15884048, ECO:0000269|PubMed:16816367, ECO:0000269|PubMed:17460351, ECO:0000269|PubMed:19837878, ECO:0000269|PubMed:20380862}. |