Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 53610
  • Symbol: Nono
  • Description: non-POU-domain-containing, octamer binding protein
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Gene ID Entry Entry Name Protein Name Type Information
53610 Q99K48 NONO_MOUSE Non-POU domain-containing octamer-binding protein (NonO protein) DISRUPTION PHENOTYPE Mutant mice display flattened nose and a smaller cerebellum. Behaviorally, mice show impaired spatial memory, as well as a marked anxiety phenotype and increased risk aversion (PubMed:26571461). Deletion leads to a significant dissociation of TET1 from chromatin and dysregulation of DNA hydroxymethylation of neuronal genes (PubMed:32286661). {ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:32286661}.