Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 53626
  • Symbol: Insm1
  • Description: insulinoma-associated 1
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Gene ID Entry Entry Name Protein Name Type Information
53626 Q63ZV0 INSM1_MOUSE Insulinoma-associated protein 1 (Zinc finger protein IA-1) DISRUPTION PHENOTYPE Mice die during the second half of gestation; lethality is caused by heart failure due to insufficient catecholamine synthesis. Display pancreatic, intestinal and sympatho-adrenal endocrine cell development impairment. Exhibits fewer terminally dividing neuronogenic basal progenitor cells (BPs) in the neocortex. {ECO:0000269|PubMed:16951258, ECO:0000269|PubMed:18094025, ECO:0000269|PubMed:18940587}.