Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 55982
  • Symbol: Paxip1
  • Description: PAX interacting (with transcription-activation domain) protein 1
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Gene ID Entry Entry Name Protein Name Type Information
55982 Q6NZQ4 PAXI1_MOUSE PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein) DISRUPTION PHENOTYPE Mice are developmentally retarded, disorganized, and embryonic lethal by 9.5 dpc. Mutant cells appear to replicate DNA but show reduced levels of mitosis and widespread cell death by 8.5 dpc. DNA damage appears to precede nuclear condensation at 7 dpc. Reduced levels of histone H3 methylated at 'Lys-4 in developing tissues. {ECO:0000269|PubMed:12588986, ECO:0000269|PubMed:17925232}.