| 58799 |
Q8C7D2 |
CRBN_MOUSE |
Protein cereblon (Protein PiL) |
DISRUPTION PHENOTYPE |
No obvious phenotype, however mice display increased BK channel activity and a subsequent decrease in synaptic transmission and presynaptic release probability in excitatory synapses (PubMed:29530986). Mice also display cognitive behavioral defects such as abnormal passive avoidance, hyperanxious behavior and decreased preference for new objects (PubMed:29530986). Treatment with the BK blocker paxilline rescues all synaptic and behavioral abnormalities except for hyperanxiety (PubMed:29530986). Brain and synaptic morphology is normal and long-term synaptic plasticity is not affected (PubMed:29530986). Conditional knockout in the forebrain results in no obvious phenotype, however mice display a deficit in contextual fear learning whereas anxiety-like behavior is unaffected (PubMed:21995942). {ECO:0000269|PubMed:21995942, ECO:0000269|PubMed:29530986}. |