Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 63873
  • Symbol: Trpv4
  • Description: transient receptor potential cation channel, subfamily V, member 4
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Gene ID Entry Entry Name Protein Name Type Information
63873 Q9EPK8 TRPV4_MOUSE Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor-rela DISRUPTION PHENOTYPE Mice display impairment of the intercellular junction-dependent barrier function in the skin (PubMed:20413591). Increased energy expenditure and improved insulin sensitivity in white adipose tissues (PubMed:23021218). Reduced Ca2+ entry and loss of regulatory volume decrease in response to hypotonicity in acinar cells (PubMed:16571723). {ECO:0000269|PubMed:16571723, ECO:0000269|PubMed:20413591, ECO:0000269|PubMed:23021218}.