Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 66411
  • Symbol: Tbcb
  • Description: tubulin folding cofactor B
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Gene ID Entry Entry Name Protein Name Type Information
66411 Q9D1E6 TBCB_MOUSE Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B) DISRUPTION PHENOTYPE Mice display significantly longer axons than wild-type mice. Overexpression of Tbcb causes microtubule depolymerization, growth cone retraction and axonal damage followed by neuronal degeneration. {ECO:0000269|PubMed:17217416}.