Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 66725
  • Symbol: Lrrk2
  • Description: leucine-rich repeat kinase 2
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Gene ID Entry Entry Name Protein Name Type Information
66725 Q5S006 LRRK2_MOUSE Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) DISRUPTION PHENOTYPE Contrary to LRRK1 knockout mice, LRRK2 knockout animals do not show obvious bone phenotypes. Osteoclast precursors differentiate into functional multinucleated cells. {ECO:0000269|PubMed:23526378}.