Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 66853
  • Symbol: Pnpla2
  • Description: patatin-like phospholipase domain containing 2
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Gene ID Entry Entry Name Protein Name Type Information
66853 Q8BJ56 PLPL2_MOUSE Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) DISRUPTION PHENOTYPE Mice show increased adipose mass and triacylglycerol deposition in multiple tissues. They accumulate large amounts of lipid in the heart, causing cardiac dysfunction and premature death. {ECO:0000269|PubMed:16675698}.