Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 66863
  • Symbol: Lztr1
  • Description: leucine-zipper-like transcriptional regulator, 1
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Gene ID Entry Entry Name Protein Name Type Information
66863 Q9CQ33 LZTR1_MOUSE Leucine-zipper-like transcriptional regulator 1 (LZTR-1) DISRUPTION PHENOTYPE Embryonic lethality between 17.5 dpc and birth (PubMed:30442762). Impaired ubiquitination of Ras (K-Ras/Kras, N-Ras/Nras and H-Ras/Hras) (PubMed:30442762). Heterozygous mice display heart malformations, including decreased left ventricular systolic function, increased diastolic dimensions, eccentric hypertrophy, increased cardiomyocyte area and reduced longevity; phenotypes that are reminiscent of human Noonan Syndrome (PubMed:30442762). {ECO:0000269|PubMed:30442762}.