Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 67834
  • Symbol: Idh3a
  • Description: isocitrate dehydrogenase 3 (NAD+) alpha
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Gene ID Entry Entry Name Protein Name Type Information
67834 Q9D6R2 IDH3A_MOUSE Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) DISRUPTION PHENOTYPE IDH3A-null homozygous mice do not survive early embryogenesis (PubMed:30478029). Compound heterozygous mice for the IDH3A-null allele and mutant p.E229K are viable and exhibit rapid retinal degeneration (PubMed:30478029). {ECO:0000269|PubMed:30478029}.