| 68020 |
Q9CQW7 |
COA8_MOUSE |
Cytochrome c oxidase assembly factor 8 (COA8) (Apoptogenic protein 1, mitochondrial) (APOP-1) |
DISRUPTION PHENOTYPE |
Mutant mice generated by CRISPR-Cas9-mediated gene editing are born at the expected Mendelian rate. They show impaired motor skills, with decreased motor coordination and endurance. Mutant show global COX deficiency with reduced enzymatic activity, low steady-state levels of structural subunits and defective assembly in all the tested tissues. {ECO:0000269|PubMed:30552096}. |