Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 68066
  • Symbol: Slc25a39
  • Description: solute carrier family 25, member 39
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Gene ID Entry Entry Name Protein Name Type Information
68066 Q9D8K8 S2539_MOUSE Probable mitochondrial glutathione transporter SLC25A39 (Solute carrier family 25 member 39) DISRUPTION PHENOTYPE Embryonic lethality at dpc 13.5 (PubMed:34707288). Embryos are pale due to a severely anemic phenotype (PubMed:34707288). Conditional deletion in the erythroid lineage also leads to severe anemia, characterized by a complete absence of Ter119(+) cells, iron overload and increased apoptosis in fetal liver cells (PubMed:34707288). Cells lacking both Slc25a39 and Slc25a40 show defects in the activity and stability of proteins containing iron-sulfur clusters (PubMed:34707288). {ECO:0000269|PubMed:34707288}.