| 71175 |
Q6KCD5 |
NIPBL_MOUSE |
Nipped-B-like protein (Delangin homolog) (SCC2 homolog) |
DISRUPTION PHENOTYPE |
Deletion of NIPBL in mouse liver leads to strong depletion of chromatin-bound cohesin and marked reorganization of chromosomal folding. Cells retain transcriptionally active (type A) and transcriptionally inactive (type B) compartments, but lose topologically associating domains (TADs) patterns and TAD-associated peaks of contact enrichment across the whole genome. The compartmentalization of chromatin in cells lacking NIPBL is enhanced around 1.8-fold compared with controls. {ECO:0000269|PubMed:29094699}. |