| Gene ID | Entry | Entry Name | Protein Name | Type | Information | 72634 | Q80VL1 | TDRKH_MOUSE | Tudor and KH domain-containing protein (Tudor domain-containing protein 2) | DISRUPTION PHENOTYPE | Male mice are sterile due to defects in male meiosis, piRNA production defects, DNA demethylation of LINE-1 (L1) transposable elements and an increase in L1 expression in the adult testis. Mutants have severely reduced levels of mature piRNAs and accumulate 1'U-containing, 2'O-methylated 31-37 nt RNAs that complement the missing mature piRNAs. {ECO:0000269|PubMed:23714778}. |
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