Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 72948
  • Symbol: Tppp
  • Description: tubulin polymerization promoting protein
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Gene ID Entry Entry Name Protein Name Type Information
72948 Q7TQD2 TPPP_MOUSE Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p25-alpha) DISRUPTION PHENOTYPE Mice display hypomyelination with shorter, thinner myelin sheaths and show breeding and motor coordination deficits (PubMed:31522887). Oligodendrocytes have thinner and more numerous branches in proximal processes (PubMed:31522887). Fewer microtubules are nucleated from Golgi outposts and these are no longer arranged in parallel bundles with their growing plus-ends distal, but show random polarity (PubMed:31522887). {ECO:0000269|PubMed:31522887}.