| 72961 |
Q3TXX4 |
VGLU1_MOUSE |
Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7) |
DISRUPTION PHENOTYPE |
Mice begin to die 3 weeks after birth. They exhibit a progressive neurological phenotype including blindness, loss of coordination and enhanced startle response. Glutamatergic neurotransmission is drastically reduced due to a decrease in the reserve pool of synaptic vesicles and reduced quantal size. Visual signaling from photoreceptors to retinal output neurons is impaired while photoentrainment and pupillary light responses remain intact. {ECO:0000269|PubMed:15103023, ECO:0000269|PubMed:15118123, ECO:0000269|PubMed:17611277}. |