Mine Disruption Phenotype

Gene Info

  • Species: Mouse (Mus musculus)
  • GeneID: 74319
  • Symbol: Mettl23
  • Description: methyltransferase like 23
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Gene ID Entry Entry Name Protein Name Type Information
74319 A2AA28 MET23_MOUSE Histone-arginine methyltransferase METTL23 (EC 2.1.1.319) (Methyltransferase-like protein 23) DISRUPTION PHENOTYPE Mice give birth to significantly smaller litter sizes (PubMed:28930672). Moreover, about a third of the homozygous newborn mice die before weaning and only a few survive to adulthood (PubMed:28930672). Strongly reduced 5-hydroxymethylcytosine (5hmC) levels in zygotes (PubMed:28930672). {ECO:0000269|PubMed:28930672}.