| 74772 |
Q9CTG6 |
AT132_MOUSE |
Polyamine-transporting ATPase 13A2 (EC 7.6.2.-) |
DISRUPTION PHENOTYPE |
No visible phenotype at 4 months (PubMed:30538141). At 10 months, gradual loss of body weight, increased liver size and reduced adipose tissue mass (PubMed:30538141). These phenotypes further progress to 18 months with significantly smaller body size, hepatomegaly, increased intracellular vacuolation in liver tissues, markedly reduced adipose tissue with small adipocytes, accumulation of autophagy receptor Sqstm1/p62 and autophagy-related protein LC3 in liver, and accumulation of ubiquitinated insoluble proteins (PubMed:30538141). {ECO:0000269|PubMed:30538141}. |