| 80707 |
Q91WL8 |
WWOX_MOUSE |
WW domain-containing oxidoreductase (EC 1.1.1.-) |
DISRUPTION PHENOTYPE |
Indistinguishable from wild-type at birth, but die after three weeks due to metabolic syndrome characterized by serum hypoproteinemia, hypoalbuminemia, hypoglycemia, hypocalcemia, hypotriglyceridemia and hypocholesterolemia, growth retardation, decreased bone formation and increased bone resorption. In addition, spontaneous tumor development was observed. {ECO:0000269|PubMed:17360458, ECO:0000269|PubMed:18487609}. |