| 93759 |
Q923E4 |
SIR1_MOUSE |
NAD-dependent protein deacetylase sirtuin-1 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)] |
DISRUPTION PHENOTYPE |
High degree of embryonic and postnatal lethality. Decreased levels of histone H3 containing a trimethyl group at its lysine 9 position (H3K9me3) in regions of heterochromatin. Attenuates spermatogenesis but not oogenesis with reduced numbers of mature sperm and spermatogenic precursors. Mice develop an autoimmune-like condition with late onset diabetes insipidus. Prostatic intraepithelial neoplasia associated with reduced autophagy. Conditional knockout in POMC neurons leads to an increase of body weight compare to controls when animals are challenged with high-fat diet (PubMed:20620997). {ECO:0000269|PubMed:12482959, ECO:0000269|PubMed:18004385, ECO:0000269|PubMed:18270565, ECO:0000269|PubMed:18687325, ECO:0000269|PubMed:20620997, ECO:0000269|PubMed:21189328}. |