| 850619 |
Q07878 |
VPS13_YEAST |
Intermembrane lipid transfer protein VPS13 (Suppression of the onset of impotence protein 1) (Vacuolar protein sorting-associated protein 13) (Vacuolar protein-targeting protein 2) |
DISRUPTION PHENOTYPE |
Compromises mitochondrial function and integrity, increases mitophagy (PubMed:27280386, PubMed:34830155, PubMed:32690699). Vacuolar protein missorting (PubMed:27280386, PubMed:28334785). Decreases number of clathrin-coated vesicles in cell (PubMed:34830155). Abnormal cortical reticulophagy; decreases packaging of endoplasmic reticulum (ER) into autophagosomes (PubMed:32690699). Abnormal sporulation; defective prospore membrane formation (PubMed:27280386, PubMed:24036347, PubMed:22442115). Accumulation of vesicles within the prospore membrane lumen and reduction of phosphatidylinositol and phosphatidic acid in the membrane (PubMed:22442115, PubMed:24036347). Abnormal actin cytoskeleton organization (PubMed:28334785). Sorting at early and late endosomes appears abnormal (PubMed:28404745). Sensitive to the arginine analog canavanine (PubMed:34830155, PubMed:28334785). Synthetic lethal with MMM1 (PubMed:26370498, PubMed:27280386). Localization of SPO71 to the prospore membrane is normal (PubMed:24036347). {ECO:0000269|PubMed:22442115, ECO:0000269|PubMed:24036347, ECO:0000269|PubMed:26370498, ECO:0000269|PubMed:27280386, ECO:0000269|PubMed:28334785, ECO:0000269|PubMed:28404745, ECO:0000269|PubMed:32690699, ECO:0000269|PubMed:34830155}. |