| 853886 |
P36112 |
MIC60_YEAST |
MICOS complex subunit MIC60 (Altered inheritance of mitochondria protein 28) (Formation of crista junctions protein 1) (Found in mitochondrial proteome protein 13) (Mitofilin) |
DISRUPTION PHENOTYPE |
Increases frequency of mitochondrial genome loss and leads to altered mitochondrial morphology. Moderately reduces mitochondrial membrane potential and import efficiency of preproteins that are transported into or across the inner membrane via TIM23 complex. Impairs precursor protein import via the MIA pathway. 60-70% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane. {ECO:0000269|PubMed:19300474, ECO:0000269|PubMed:21944719, ECO:0000269|PubMed:21987634}. |