Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 171647
  • Symbol: wwp-1
  • Description: E3 ubiquitin-protein ligase wwp-1
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Gene ID Entry Entry Name Protein Name Type Information
171647 Q9N2Z7 WWP1_CAEEL E3 ubiquitin-protein ligase wwp-1 (EC 2.3.2.26) DISRUPTION PHENOTYPE RNAi-mediated knockdown increases sensitivity to paraquat, and reduces lifespan at 25 degrees Celsius, but not at 20 degrees Celsius (PubMed:19553937). Causes reduced ability of dietary restriction to extend lifespan (PubMed:24805825, PubMed:19553937). Abolishes lifespan extension completely on an eat-2 mutant background, independent of whether knockdown is ubiquitous, or targeted only to the intestine (PubMed:24805825, PubMed:19553937). Does not suppress extended lifespans of isp-1 or daf-2 mutants (PubMed:19553937). Hypersensitive to bacterial pore-forming toxin (PubMed:20209166). {ECO:0000269|PubMed:19553937, ECO:0000269|PubMed:20209166, ECO:0000269|PubMed:24805825}.