| 172041 |
Q19020 |
DYHC_CAEEL |
Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown prevents sperm-donated centrosome from leaving the posterior cortex in 1-cell embryos (PubMed:20599902). RNAi-mediated knockdown results in nuclear migration defects in hyp7 hypodermal precursor cells (PubMed:20005871). RNAi-mediated knockdown in a pam-1 mutant background restores anterior-posterior polarity, par-1, par2 and par-6 asymmetric localization and pseudocleavage formation (PubMed:20599902). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown in combination with exposure to pentylenetetrazole, a GABA antagonist that induces seizures, results in an increased convulsion incidence as compared to wild-type animals (PubMed:16996038). RNAi-mediated knockdown in a fbf-2 loss of function background results in sterility and the formation of small endomitotic oocytes (PubMed:27864381). {ECO:0000269|PubMed:16996038, ECO:0000269|PubMed:20005871, ECO:0000269|PubMed:20599902, ECO:0000269|PubMed:27864381}. |