Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 172148
  • Symbol: mtm-1
  • Description: Phosphatidylinositol-3,5-bisphosphate 3-phosphatase mtm-1
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Gene ID Entry Entry Name Protein Name Type Information
172148 Q9N589 MTMR1_CAEEL Myotubularin-related protein 1 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64) DISRUPTION PHENOTYPE RNAi-mediated knockdown causes an increase in PI3P levels in intracellular vesicles. Also causes an increase in germline cell corpse engulfment, although corpses fail to be cleared. RNAi-mediated knockdown in ced-1, ced-6, ced-2, ced-10 or ced-7 mutant background partially restores cell corpses engulfment. {ECO:0000269|PubMed:19816564, ECO:0000269|PubMed:21490059}.