Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 172591
  • Symbol: apr-1
  • Description: Adenomatous polyposis coli protein;Adenomatous polyposis coli protein-related protein 1
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Gene ID Entry Entry Name Protein Name Type Information
172591 Q21227 APR1_CAEEL Adenomatous polyposis coli protein-related protein 1 (APC-related protein 1) DISRUPTION PHENOTYPE Worms exhibit lack of endoderm, excessive pharyngeal tissue and premature division of the E daughter blastomeres during embryogenesis. Two-thirds arrest during embryogenesis and the remaining third during the L1 stage (PubMed:9288750). RNAi-mediated knockdown causes partial nuclear re-localization of hmp-2 in the embryonic epidermis and the production of supernumerary gut nuclei probably resulting from epithelial cell hyperproliferation (PubMed:20805471). {ECO:0000269|PubMed:20805471, ECO:0000269|PubMed:9288750}.