| 172981 |
O16850 |
FOXO_CAEEL |
Forkhead box protein O (FOXO) (Abnormal dauer formation protein 16) |
DISRUPTION PHENOTYPE |
Dauer defective phenotype in larvae and a reduced stress phenotype in adults (PubMed:9360933). Increased carbonyl accumulation and increased sensitivity to starvation (PubMed:18025456). Increased expression of the srh-234 chemoreceptor during starvation (PubMed:25357003). Increased sensitivity to physical injury and more susceptible to death by nematophagous fungal infection (PubMed:24146615). Increased lifespan (PubMed:23805378). Causes a delay in apoptosis during embryonic development (PubMed:25383666). Defective gustatory associative learning in response to salt cues (PubMed:30779740). RNAi-mediated knock-down reduces expression of daf-16 target genes and genes up-regulated in response to nematophagous fungal infection such as sod-3 (PubMed:24146615). RNAi-mediated knockdown causes reduced ability of dietary restriction to extend lifespan (PubMed:17900900). Simultaneous RNAi-mediated knockdown of metalloproteinase zmp-2 restores normal survival upon heat stress and prevents increased susceptibility to heat stress in a daf-9 or daf-12 mutant background (PubMed:24957743). RNAi-mediated knockdown in a daf-2 (e1370) mutant background restores expression of deubiquitinase ubh-4 in the intestine (PubMed:23770237). RNAi-mediated knockdown suppresses the decreased number of mitotic nuclei in the germline of developing larvae in an atg-18 (gk378) or atg-16.2 (ok3224) mutant background. Suppresses associative memory, axon regeneration and fkh-9 transcript levels, in a daf-2 mutant background. RNAi-mediated knockdown in the first generation offspring (F1) of adults fed a high-fat diet prevents lipid accumulation (PubMed:35140229). {ECO:0000269|PubMed:17900900, ECO:0000269|PubMed:18025456, ECO:0000269|PubMed:23770237, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:24146615, ECO:0000269|PubMed:24957743, ECO:0000269|PubMed:25357003, ECO:0000269|PubMed:25383666, ECO:0000269|PubMed:26675724, ECO:0000269|PubMed:30779740, ECO:0000269|PubMed:9360933}. |