Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 172984
  • Symbol: spt-16
  • Description: FACT complex subunit spt-16
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Gene ID Entry Entry Name Protein Name Type Information
172984 Q9N5R9 SPT16_CAEEL FACT complex subunit spt-16 (Facilitates chromatin transcription complex subunit spt-16) DISRUPTION PHENOTYPE RNAi-mediated knockdown in embryos results in failed hatching in 83% of animals (PubMed:30336114). In addition, these embryos lack the anterior pharynx (PubMed:30336114). RNAi-mediated knockdown at the L4 larval stage results in failed development of the anterior pharynx (PubMed:30336114). RNAi-mediated knockdown at this stage results in defective cell cycle initiation, duration and completion in embryos, and abnormalities in chromosome segregation (PubMed:25446273, PubMed:30336114). {ECO:0000269|PubMed:25446273, ECO:0000269|PubMed:30336114}.